bleeding disorders in women
CLINICAL PRACTICE GUIDELINES
Hemophilia and von Willebrand's disease: 2. Management
(Edition 2, Update 2 [1999-07-07])
As the inheritance of von Willebrand's disease is autosomal,
equal numbers of women and men are affected. However, the clinical
manifestations of this typically mild bleeding disorder are
often much more prominent in women, in whom menorrhagia is
a frequent manifestation. Furthermore, women who are hemophilia
carriers may have sufficiently low factor VIII or factor IX
levels to have excessive bleeding following trauma or surgery.
Rarely, carriers with extreme Lyonization may have factor levels
as low as the more typical male patient with hemophilia and
similarly severe clinical bleeding problems.
For women with von Willebrand's disease, gynecological bleeding
can be an additional problem. Physicians should be aware that
menorrhagia may be related to an underlying bleeding disorder
in addition to gynecological causes. Useful agents in management
include desmopressin, antifibrinolytics and oral contraceptives,
alone or in combination.
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INTERNATIONAL PHARMACEUTICAL ABSTRACTS
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BIOLOGICAL ABSTRACTS
OTHER VON WILLEBRAND SEARCHES
BLEEDING DISORDERS IN WOMEN
BLOOD COMPONENTS
COMPREHENSIVE CARE
FAMILY INVOLVEMENT IN CARE
GENETIC COUNCELING
DISEASE MANAGEMENT
PRE-OPERATIVE ASSESSMENT