CLINICAL PRACTICE GUIDELINES
Hemophilia and von Willebrand’s Disease: 2. Management
(Edition 2, Update 2 [1999-07-07])

Factor VIII concentrates (hemophilia A)
The following types of concentrate are available for treatment of hemophilia A:
• Recombinant Factor VIII (rFVIII) concentrate. The clotting factor is produced in cultured hamster cells in the presence of human plasma protein fractions, purified with the use of procedures which include immunoaffinity chromatography on murine monoclonal antibodies, and formulated with human serum albumin as stabilizer.
• Very-high-purity plasma-derived Factor VIII concentrate purified by immunoaffinity chromatography and stabilized in human serum albumin.